IsoScreen

Physics-first docking, scoring, and screening.

IsoScreen

IsoScreen - Physics-First Molecular Scoring

Dock, score, and screen with zero fitted parameters. Three tools, one physics engine.

IsoPose

Dock your ligands. GPU-accelerated AMR docking generates poses directly in your browser at hundreds of ligands per second. No server queue, no installation.

Start Docking →

IsoScore

Score your poses. 14 ab initio physics terms evaluate every pose from pocket geometry alone. No fitted parameters, fully interpretable.

Score Poses →

IsoScreen

Screen your library. Universal scoring combines physics terms using geometric routing laws to discriminate actives from inactives. 0.916 mean AUC across 178 validated targets.

Run Screening →

Quick Start

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Benchmark Summary

0.897 DUD-E mean AUC, 87 targets
0.942 DEKOIS2 mean AUC, 76 targets
0.890 LIT-PCBA mean AUC, 15 held-out targets
0.916 Combined mean AUC, 178 targets