Benchmark Results
As of March 15, 2026, the live IsoPose registry at /static/wasm/demo_assets/isopose_targets_v1.json contains 48 GOLD_LOCKED entries:
- 46 launch-roster targets
- 2 native-docking variants (
CDK2 (Native Docking) and P38A (Native Docking))
This page replaces the older 14-target snapshot with the current registry-backed benchmark table.
How These AUCs Are Collected
- Values are pulled from the target bundles referenced by the live registry.
- The page prefers bundle-level benchmark fields in this order:
manifest.auc, manifest.validation.full_set_auc, manifest.validation.expected_auc, then explicit registry promotion fields or lock notes when the manifest only stores routing overrides.
- Launch-roster targets are listed separately from native variants so the public launch set stays easy to scan.
Reading The Table
| AUC |
Interpretation |
>= 0.90 |
Excellent discrimination |
0.80 - 0.899 |
Strong validation signal |
0.70 - 0.799 |
Launch-usable with clear caveats |
< 0.70 |
Gold-locked only where the bundle is intentionally retained for an honest product path or a native-variant diagnostic track |
Registry Snapshot
- Launch roster: 46/46
GOLD_LOCKED
- Native variants: 2/2
GOLD_LOCKED
- Docs note: the benchmark table now mirrors the live bundle metadata instead of a hand-maintained subset list
Launch Roster
| Target |
Family |
Current AUC |
Source |
| A2A |
GPCR |
0.816 |
Bundle expected validation |
| ACE (Geometric) |
General |
0.979 |
Bundle full-set validation |
| ACE (IsoPose) |
Metalloprotease |
0.979 |
Bundle full-set validation |
| AChE |
General |
0.842 |
Registry reference lock |
| ADRB2 (IsoPose) |
General |
0.834 |
Bundle manifest |
| AKT1 |
General |
0.850 |
Bundle manifest |
| AmpC |
General |
0.827 |
Bundle expected validation |
| AR |
General |
0.721 |
Bundle manifest |
| AURKA |
General |
0.818 |
Bundle manifest |
| BACE1 |
Aspartyl Protease |
0.941 |
Bundle expected validation |
| BCL2 |
General |
0.768 |
Bundle/lock note |
| BRAF |
General |
0.888 |
Bundle manifest |
| CATL |
General |
0.842 |
Bundle manifest |
| CDK2 |
Kinase |
0.756 |
Bundle full-set validation |
| COX2 (IsoPose) |
General |
0.894 |
Bundle manifest |
| CTSK |
General |
0.804 |
Bundle manifest |
| DHFR (IsoPose) |
General |
0.879 |
Bundle manifest |
| EGFR |
Kinase |
0.933 |
Bundle expected validation |
| ESR1 |
Nuclear Receptor |
0.839 |
Bundle full-set validation |
| FKBP1A |
General |
0.939 |
Bundle manifest |
| FXa |
Serine Protease |
0.792 |
Bundle expected validation |
| GBA |
General |
0.806 |
Bundle expected validation |
| HDAC2 |
General |
0.985 |
Bundle expected validation |
| HIV1PR (IsoPose) |
General |
0.928 |
Bundle manifest |
| HIVRT (IsoPose) |
General |
0.700 |
Registry wave3 promotion |
| HMGR |
General |
0.946 |
Bundle manifest |
| HSP90 |
Chaperone |
0.844 |
Bundle expected validation |
| JAK2 |
General |
0.908 |
Bundle manifest |
| JNK1 |
General |
0.604 |
Bundle/lock note |
| MCL1 |
PPI hotspot |
0.915 |
Bundle expected validation |
| MDM2 (IsoPose) |
PPI hotspot |
0.849 |
Bundle full-set validation |
| MMP2 |
General |
0.705 |
Bundle manifest |
| NA |
General |
0.942 |
Bundle manifest |
| P38A |
Kinase |
0.826 |
Bundle expected validation |
| PARP1 |
DNA repair |
0.786 |
Bundle expected validation |
| PDE5 |
General |
0.877 |
Bundle full-set validation |
| PNP |
General |
0.832 |
Bundle manifest |
| PPARA |
General |
0.917 |
Bundle manifest |
| PPARG (IsoPose) |
General |
0.670 |
Registry wave3 promotion |
| RXR |
General |
0.974 |
Bundle full-set validation |
| SIRT2 |
General |
0.772 |
Bundle manifest |
| SRC (IsoPose) |
General |
0.759 |
Bundle manifest |
| Thrombin |
Serine Protease |
0.800 |
Bundle expected validation |
| TS |
General |
0.836 |
Bundle manifest |
| UROK |
General |
0.792 |
Bundle expected validation |
| VEGFR2 |
General |
0.733 |
Bundle manifest |
Native Variants
| Target |
Family |
Current AUC |
Source |
| CDK2 (Native Docking) |
Kinase |
0.700 |
Bundle expected validation |
| P38A (Native Docking) |
Kinase |
0.826 |
Bundle expected validation |
Notes
Bundle manifest means the pack ships a direct auc value in manifest.json.Bundle full-set validation and Bundle expected validation come from the bundle's validation block and are used where the product path is pinned to the validated benchmark configuration.Registry reference lock, Registry wave3 promotion, and Bundle/lock note appear only where the gold-lock decision was recorded outside the standard manifest fields.- Some families are shown as
General because the bundle metadata does not currently provide a more specific class label.